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KMID : 0359320160560040241
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Korean Journal of Veterinary Research
2016 Volume.56 No. 4 p.241 ~ p.247
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Hangover relieving effect of Sanghwang mushroom mycelium extract
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Kim Min-Su
An Yoo-Jin
Lee Jae-Chul
Park Ga-Ryoung
Park Dong-Soo
Jeon Nam-Gen
Lee Young-Jae
Han Chang-Hoon
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Abstract
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This study was conducted to evaluate the hangover relieving effect of Sanghwang mushroom mycelium extract (SME). The extract showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging effect in a concentration-dependent manner and high antioxidant capacity (56.67 ± 1.77%) when administered at 120 μg/mL. In addition, SME significantly increased (p < 0.005) the aldehyde dehydronase (ALDH) activity (126.03 ± 9.11%) when applied at 8 or 16 μL/mL. A locomotor activity test showed that the alcohol-water treated group showed significantly decreased motor activity at 90 min post-administration. However, the alcohol-SME treated group showed a 20-fold higher motor activity than that observed in the alcohol-water treated group at 90 min post-administration. Blood was harvested from each mouse at 90 min post-administration, and both alcohol and aldehyde concentrations were measured. The alcohol-SME treated group showed significantly lower (p < 0.5) alcohol (120.13 ± 12.83 μg/mL) and aldehyde (7.26 ± 1.22 μg/mL) concentrations than the values observed in the alcohol-water treated group. These results suggest that the hangover relieving effect of SME results from increased ALDH activity, which reduces the aldehyde concentration in the blood.
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KEYWORD
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blood aldehyde concentration, hangover relieving effect, locomotor activity test, Sanghwang mushroom mycelium extract
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